By Jacob Bean
Works mentioned in Abbreviated Form
Notices and Illustrations
Index of Former Owners
Index of Artists
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Extra info for 17th century Italian drawings in the Metropolitan Museum of Art
In addition, this project will investigate the distribution and expression of DMT1, hephaestin, Ireg1 and SFT in these human subjects and animal models. These studies will be integrated with a more detailed analysis of HFE trafficking and processing, including the precise nature of the assembly, localization, transport and degradation of the HFE molecule. This knowledge will provide an avenue for the development of therapeutics aimed at increasing the secretion and transport of the mutated form of HFE to the compartment where it is active.
Despite the clinical prevalence of iron deficiency and iron overload, dietary iron uptake is poorly understood. The investigation of a unique mammalian model of iron deficiency anemia, the sla mouse, has revealed a fundamental component of intestinal iron transport. Sla mice take up iron from the intestinal lumen but have greatly diminished export of iron out of transmembrane-bound ceruloplasmin homologue highly expressed in the mature absorptive cells of the small intestine, the primary site of iron uptake in gastrointestinal tract.
We hypothesize that women receiving calcium supplements will have less lead mobilization and thus less transfer to their developing Studies 31 child. We will also assess whether calcium plus vitamin supplements is more protective than calcium alone. This study will be undertaken in Morelos, Mexico where the population has high environmental lead exposure, predominantly through the use of lead-glazed ceramics, and where women have high rates of breast-feeding. Thus we will be able to compare bone-lead mobilization during lactation with that which occurs during pregnancy.