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Additional info for Autism - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
During the initial phase of this center we will concentrate on the establishment of an organizational structure to facilitate the development of junior and established investigators as autism researchers and on the creation of an enhanced integration of clinical and educational programs in autism and related disorders. Pilot studies for this developmental period will include extension of instruments developed for children to adult versions to test for extended familial transmission of autistic traits and the piloting of the use of established instruments in a quantitative trait locus (QTL) Studies 25 analysis of the possible involvement of the X chromosome in deficits in reciprocal social behaviors.
4) Genotype and phenotype of autism spectrum disorders (Rodier). s work linking injury during early development (as early as neural tube fusion) and specific genes with the development of the autism disorders. Work will continue to examine the valproic acid model of brain injury (which phenocopies some aspects of autism spectrum disorders), and the toxicant involves the HOX family of genes. 5) The role of inflammation and oxidative stress in human immunodeficiency virus type 1- associated neurologic disease (Gelbard).
19 Firstfield Rd Gaithersburg, Md 20878 Timing: Fiscal Year 2002; Project Start 01-MAY-2002; Project End 31-OCT-2002 Summary: (provided by applicant): Using a high-throughput robotic system we plan to screen a library of 70,000 small molecules (each <700 daltons) for agonists at the secretin receptor transfected into cells. Small molecule non-peptide agonists at this receptor may overcome some of the anticipated issues with administration of the peptide hormone in the treatment of patients with Autistic disorders, such as its short in vivo half life, its need to be administered by injection and its pharmacokinetic parameters.